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Role of centromeres in mitosis and meiosis

During mitosis, spindle fibres attach to the centromere and control its position in the cell. The centromere divides when the fibres contract.

This allows the two sister chromatids to move to opposite sides of the cell, leading to nuclear division.

In meiosis I, the centromeres remain intact to ensure that the two sister chromatids remain together. The homologous chromosomes separate but the chromatids remain together.

Subsequently, during meiosis II the centromeres divide. This separates the sister chromatids.

These chromosomes are in metaphase. The centromere of one is indicated in red.
These chromosomes are in metaphase. The centromere of one is indicated in red.