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Translation mechanism: Termination

Translation ends in termination. At this stage, the ribosome reaches the stop codon at the end of the mRNA coding sequence.

tRNA cannot bind to the stop codon because stop codons do not code for amino acids. Once the ribosome reaches the stop codon, translation ends.

The ribosomal subunits then break apart, releasing the polypeptide chain.

The new polypeptide may combine with other polypeptides or split into smaller fragments before becoming a functional protein.

It is possible for many ribosomes to bind to an mRNA chain along its length and simultaneously produce proteins.