The primary structure of a protein is the sequence of amino acids in the protein. The amino acid sequence is encoded by genes in the DNA.
The only bonds relevant for the primary structure of a protein are the peptide bonds between individual amino acids.
The sequence of amino acids dictates the overall structure of the protein, because their R-groups influence the folding and bonding at every level of the protein structure.
Small changes in the primary structure can result in an alteration of the protein's function.
Sickle cell anaemia is a genetic disease that arises from the change in one amino acid in the primary structure of a protein.